The statistical associating fluid theory (SAFT) equation of state is employed for the prediction of the thermodynamic inhibiting effect of methanol, glycerol, ethylene glycol, and triethylene glycol on gas hydrate formation. The results were found to be in satisfactory to excellent agreement with experimental data. The SAFT equation takes into account hard-sphere repulsion, hard chain formation, dispersion, and association. This enables this model to be able to correlate and predict successfully systems containing water, alcohols, and hydrocarbons for which traditional cubic equations of state fail in general.