We investigate a reactor network consisting of two chemostats in series. Previous researchers have compared the performance of a two-reactor system against a single reactor having the same total residence time. In this paper, we suggest that it is more natural to compare the performance of a cascade against the optimal performance a single-reactor system having the same, or smaller, residence time. We consider a biological system in which the growth rate is given by a Monod expression with a variable yield coefficient. We find that it is possible for this model to obtain a significant increase in performance by using a two-reactor system. However for the two-reactor system the performance enhancements are achieved when the system reaches a time-invariant steady-state rather than under conditions which produce self-generated oscillations, which was the focus of interest of earlier researchers. (c) 2006 Elsevier Ltd. All rights reserved.