화학공학소재연구정보센터
Journal of the American Chemical Society, Vol.128, No.10, 3414-3419, 2006
Synthesis of the Trypanosoma cruzi LPPG heptasaccharyl myo-inositol
Synthesis of the heptasaccharyl myo-inositol found in Trypanosorna cruzi lipopeptidophosphoglycan was accomplished using a convergent assembly of three building blocks. The target compound is the first complete 2-aminoethyl phosphonic acid substituted glycan related to the glycosylphosphatidylinositol anchor family to be synthesized. The order of assembly enables synthesis of phosphoinositol oligosaccharicles related to other glycosylinositolphospholipids in Tr. cruzi, the protozoan parasite causing Chagas' disease, which is endemic in South America.