Evaluation of New Selective Molecularly Imprinted Polymers for the Extraction of Resveratrol from Polygonum Cuspidatum

Hui Cao; Jian Bo Xiao; Ming Xu

Macromolecular Research, Vol.14, No.3, 324-330, June, 2006

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Evaluation of New Selective Molecularly Imprinted Polymers for the Extraction of Resveratrol from Polygonum Cuspidatum

Hui Cao¹, Jian Bo Xiao^{2, †}, and Ming Xu^{3, 4}

¹School of Chemistry and Chemical Engineering, Nantong University, Nantong 226000, China
²College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
³Research Institute for Molecular Pharmacology and Therapeutics, Central South University, Changsha 410083, China
⁴Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York 10021, China

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Four different molecularly imprinted polymers (MIPs) were prepared using resveratrol as the template, methacrylic acid (MAA) or acrylamide (AA) as functional monomers, 2, 2-azobisisobutyronitrile (AIBN) as the initiator, and thermo- or photo-induced polymerization. The ability of the different polymers to rebind selectively not only the template but also other phenols was evaluated. In parallel, the influence of the different templates and functional monomers used during polymer syntheses on the performance of the obtained MIPs was also studied through different rebinding experiments. The binding ability and selectivity of the polymer were studied by static balance method and Scatchard analysis. It was concluded that AA-based polymer by photo-induced polymerization presents the best properties to be used as a selective absorbent for the extraction of resveratrol.

Keywords:molecularly imprinted polymers;resveratrol;isotherms;binding sites

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[Referenced By]

[1] Mayes AG, Mosbach K, Trends Anal. Chem., 16, 321 (1997)

[2] Cormack PAG, Elorza AZ, J. Chromatogr. B, 804, 173 (2004)

[3] Donga W, Yan M, Zhang ML, Liu Z, Li YM, Anal. Chim. Acta, 542, 186 (2005)

[4] Mahony JO, Molinelli A, Nolan K, Smyth MR, Mizaikoff B, Biosens. Bioelectron., 21, 1383 (2006)

[5] Kriz D, Mosbach K, Anal. Chim. Acta, 300, 71 (1995)

[6] Guo TY, Xia YQ, Wang J, Song MD, Zhang BH, Biomaterials, 26, 5737 (2005)

[7] Baggiani C, Anfossi L, Baravalle P, Giovannoli C, Tozzi C, Anal. Chim. Acta, 531, 199 (2005)

[8] Elhiney JM, Lawton LA, Toxicol. Appl. Pharmacol., 203, 219 (2005)

[9] Mahony JO, Nolan K, Smyth MR, Mizaikoff B, Anal. Chim. Acta, 534, 31 (2005)

[10] Suedee R, Srichana T, Sangpagai C, Tunthana C, Vanichapichat P, Anal. Chim. Acta, 504, 89 (2004)

[11] Feng L, Liu YJ, Zhou XD, Hu JM, J. Colloid Interface Sci., 284(2), 378 (2005)

[12] Matsuguchi M, Uno T, Sens. Actuators B-Chem., 113, 94 (2006)

[13] Bastide J, Cambon JP, Breton F, Piletsky SA, Rouillon R, Anal. Chim. Acta, 542, 97 (2005)

[14] Hu SG, Li L, He XW, J. Chromatogr. A, 1062, 31 (2005)

[15] Coutinho D, Acevedo AO, Dieckmann GR, Microporous Mesoporous Mater., 54, 249 (2002)

[16] Zhou L, Xie JC, Ge YF, Acta. Phys. Chim. Sin., 18, 808 (2002)

[17] Soleas GL, Diamandis EP, Goldberg DM, Clin. Biochem., 30, 91 (1997)

[18] Fremont L, Life Sci., 66, 663 (2000)

[19] Soto VG, Drug News Perspect, 16, 299 (2003)

[20] Wu NM, Wang ZR, Hsieh TC, Bruder JL, Zou JG, Huang YZ, Int. J. Mol. Med., 8, 3 (2001)

[21] Bianchini F, Vainio H, Eur. J. Cancer Prev., 12, 417 (2003)

[22] Syu MJ, Deng JH, Nian YM, Anal. Chim. Acta, 504, 167 (2004)