A porous anion exchange hollow fiber membrane were prepared by radiation-induced graft polymerization. the irradiated membrane was immersed in glycidyl methacrylate(GMA). The epoxy group produced in GMA hollow fiber membrane was coverted into anion exchange groups by reaction with ethanolamine(EtA). diethylamine(DEA). and diethanolamine(DEtA). A lipase solution was allowed to permeate through the porous anion exchange hollow fiber membrane. The concentration of lipase in the effluent penetrationg the outside surface of the exchange hollow fiber were determined from UV absorption at 280nm. EtA membrane was the most adsorption capacity in different membranes.