To expand applications for gas separation membranes, material research must not only identify attractive candidate polymers. Transformation of these materials into an industrially relevant form is equally important. Asymmetric hollow fibers are attractive forms for high volume gas separation applications, and this paper describes an approach for developing first-gene ration asymmetric hollow fiber gas separation membranes using small amounts of novel, experimental polymers. The techniques connect easily determined polymer properties with spinning parameters to allow high-speed fiber spinning. A case study using a crosslinkable polyimide is discussed to illustrate the method. (c) 2005 Elsevier B.V. All rights reserved.