Basic features of a simulation tool developed to enable tailor made design of shell and tube modules for vapor permeation are demonstrated. The predictive model describes a ceramic membrane module using the resistance-in-series model, that accounts for concentration polarization and support layer contributions. Using ethanol dehydration as base case, a parametric study is carried out to demonstrate the effects associated with changes in variables such as feed flow rate, feed pressure, module feed side, ideal separation factor and tube diameter. From the outcome of these simulations, basic rules to qualitative predict the performance of vapor permeation modules are suggested. (c) 2006 Elsevier B.V. All rights reserved.