The experimental investigation of the Selective Catalytic Reduction (SCR) of NO, with NH3 in a Simulated Moving Bed (SMB) reactor realized by means of a network of three catalyst beds with periodical variation of the feed position is dealt with. The influence of the main operating parameters, namely, the inlet flow rate, the switching frequency, and the working temperature, has been investigated, as well as the responses of this device to disturbances in the feeding. A simple one-dimensional (1-D) model has been validated by means of the comparison with the experimental results. (c) 2006 American Institute of Chemical Engineers.