For optimization-based dynamic control of simulated moving bed (SMB) process, a novel control strategy based on process identification, which is an extension of the earlier work (Song et al., 2006a. Identification and predictive control of a simulated moving bed process: purity control. Chemical Engineering Science 61, 1973-1986), is proposed. A linear output prediction model is obtained by the method of subspace identification and used for the dynamic control. The controller is designed for optimizing the production cost while maintaining the specified product purities. For all of these, the average purities over one switching period of the target components in extract and raffinate streams, the reciprocal productivity and the solvent consumption are selected as output variables, while the flow rates in Sections 1-4 are chosen as the manipulated variables. The realization of this concept is discussed and assessed on a virtual eight column SMB unit for a system following a bi-Langmuir isotherm. The identified prediction model is proven to be in good agreement with the first principles model considered as the actual SMB process. For typical control objectives encountered in actual operation, i.e., disturbance rejection and set-point tracking, it is shown that the proposed controller exhibits excellent performance, hence it is an effective tool for optimization-based control of SMB process. (c) 2006 Elsevier Ltd. All rights reserved.