A new hydrogel that combines poly(ethylene glycol) and beta-cyclodextrin has been synthesized. Both components are linked by using a diisocyanate (HDMI), first by end-capping the poly(ethylene glycol) with isocyanate groups an then reacting it with beta-cyclodextrin, forming urethane links. Hydrogels of molar compositions (beta-cyclodextrin/poly(ethylene glycol)) ranging from 1/4 to 1/14 have been synthesized. These hydrogels swell quickly and their water contents depend upon temperature. The gels are temperature resistant and show an elastomeric behavior. (c) 2006 Wiley Periodicals, Inc.