Petroleum reservoir fluids are normally produced with saline water. One serious problem in production and transportation of these fluids is pipeline blockage due to hydrate formation giving rise to operational problems and other safety concerns. No means of controlling and monitoring are generally available along the pipelines and/or downstream to assess hydrate formation. High safety margins are used in many cases to account for the uncertainties in the operating conditions and to reduce the gas hydrate formation risks. In this work, the possibility of predicting the hydrate safety margin from surface tension data of salt aqueous solutions is investigated using a new equation. The developed method considers only the changes in surface tension of saline water with respect to surface tension of distilled water, and therefore there is no need to have the analytical analysis of the aqueous solution. Independent data are used to examine the reliability of this tool. The predictions of this method are in acceptable agreement with the independent data, demonstrating its reliability for estimating the hydrate safety margin in the presence of salt aqueous solutions.