Cryogels of non-ionic (hydroxypropyl)methylcellulose, 2-hydroxyethylcellulose, methylcellulose and cationic hydroxyethylcelluloses were prepared for the first time via UV irradiation of moderately frozen systems. The influence of the irradiation time, the concentration of the photo-initiator (4-benzoylbenzyl)trimethylammonium chloride, and the concentration of the polymer solution on the efficiency of the cross-linking process in moderately frozen systems was investigated. It was found that 2-min irradiation at an irradiation dose rate of 5.7 J/cm(2) min is adequate for cross-linking of 3 wt.% polymer solutions resulting in high quality cryogel. (c) 2006 Elsevier Ltd. All rights reserved.