Octasubstituted Cyclotetraphosphazene으로부터 Vesicle의 형성

신영재; 박철순; 김주연; 김세라; 신재섭; Young Jae Shin; Chul Soon Park; Ju Youn Kim; Se Ra Kim; Jae Sup Shin

Journal of the Korean Industrial and Engineering Chemistry, Vol.18, No.1, 54-57, February, 2007

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Octasubstituted Cyclotetraphosphazene으로부터 Vesicle의 형성

Preparation of Vesicles Using Octasubstituted Cyclotetraphosphazene

신영재, 박철순¹, 김주연¹, 김세라¹, 신재섭 ^{1, †}

한국과학기술원 전자전산학과
¹충북대학교 화학과ㆍ기초과학연구소

Young Jae Shin, Chul Soon Park¹, Ju Youn Kim¹, Se Ra Kim¹, and Jae Sup Shin^{1, †}

Department of Electrical Engineering and Computer Science, KAIST, Daejeon, 305-701, Korea
¹Department of Chemistry and Basic Sciences Research Institute, Chungbuk National University, Cheongju, Chungbuk 361-763, Korea

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초록

Octachlorocyclotetraphosphazene을 사용하여 cyclotetraphosphazene 구조를 내부에 갖고 외부로 8개의 사슬 구조를 갖는 cyclotetraphosphazene 유도체를 합성하였다. 그리고 이 유도체와 콜레스테롤을 사용하여 vesicle을 형성시켰으며, TEM을 이용해서 이 vesicle의 형태를 살펴보고, encapsulation 효율 등을 알아보았다. 이 vesicle의 안정도는 dihexadecylphosphate를 첨가함에 의해서 크게 향상되었다.

A cyclotetraphosphazene derivative having eight chains was synthesized from octachlorocyclotetraphosphazene, which was employed along with cholesterol for the preparation of vesicles. The resulting vesicles were characterized by TEM and encapsulation efficiency. The stability of the vesicles was enhanced in the presence of dihexadecylphosphate.

Keywords:cyclotetraphosphazene;vesicle;cholesterol;encapsulation

[References]

Fendler JH, Accounts Chem. Res., 13, 7 (1980)
Fendler JH, Membrane Mimetic Chemistry, 160, John Wiley & Sons, New York (1982)
Tunuli MS, Fendler JH, J. Am. Chem. Soc., 103, 2507 (1981)
Tricot YM, Fendler JH, J. Am. Chem. Soc., 106, 7359 (1984)
Moss RA, Shin JS, J. Chem. Soc., Chem. Commun., 1027 (1983)
Moss RA, Bhattacharya S, Scrimin P, Swarup S, J. Am. Chem. Soc., 109, 5740 (1987)
Moss RA, Okumura Y, J. Am. Chem. Soc., 114, 1750 (1992)
Cho I, Shin JS, Polym.(Korea), 15(2), 170 (1991)
Shin JS, J. Korean Ind. Eng. Chem., 2(1), 64 (1991)
Bae DH, Kim KS, Shin JS, J. Korean Ind. Eng. Chem., 3(2), 335 (1992)
Cho I, Chung KC, Macromolecules, 17, 2935 (1984)
Cho I, Chung KC, Macromolecules, 21, 565 (1988)
Cho I, Park JG, Chem. Lett., 977 (1987)
Cho I, Kim YW, Polym. Bull., 24, 545 (1990)
Cho I, Kim SH, Shin JS, J. Korean Ind. Eng. Chem., 3(2), 273 (1992)
Cho I, Jeong SW, Shin JS, Polym.(Korea), 18(1), 23 (1994)
Shin JS, Polym.(Korea), 19(3), 379 (1995)
Shin JS, J. Korean Ind. Eng. Chem., 7(6), 1142 (1996)
Shin JS, J. Korean Ind. Eng. Chem., 9(5), 763 (1998)
Allcock HR, Chem. Mater., 6, 1476 (1994)
Allcock HR, Phosphorus-Nitrogen Compounds, Academic Press, New York (1972)
Kumar D, Gupta AD, Khullar M, J. Polym. Sci. A: Polym. Chem., 31, 707 (1993)
Horacek H, Pieh S, Polym. Int., 49, 1106 (2000)
Wu Q, Lu J, Qu B, Polym. Int., 52, 1326 (2003)
Levchik SV, Levchik GF, Balabanovich AI, Weil ED, Klatt M, Angew. Makromol. Chem., 264, 48 (1999)
Zhu WM, Weil ED, Mukhopadhyay S, J. Appl. Polym. Sci., 62(13), 2267 (1996)
Kim HY, Shin YJ, Ji YJ, Shin JS, J. Korean Ind. Eng. Chem., 17(2), 144 (2006)
Gleria M, Jaeger RD, Phosphazenes, Nova Science Publishers, New York (2004)
Chang JY, Rhee SB, Cheong S, Yoon M, Macromolecules, 25, 2666 (1992)
Chang JY, Ji HJ, Han MJ, Rhee SB, Cheong S, Yoon M, Macromolecules, 27(6), 1376 (1994)
Chang JY, Park PJ, Han MJ, Macromolecules, 33, 321 (1998)

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[1] Fendler JH, Accounts Chem. Res., 13, 7 (1980)

[2] Fendler JH, Membrane Mimetic Chemistry, 160, John Wiley & Sons, New York (1982)

[3] Tunuli MS, Fendler JH, J. Am. Chem. Soc., 103, 2507 (1981)

[4] Tricot YM, Fendler JH, J. Am. Chem. Soc., 106, 7359 (1984)

[5] Moss RA, Shin JS, J. Chem. Soc., Chem. Commun., 1027 (1983)

[6] Moss RA, Bhattacharya S, Scrimin P, Swarup S, J. Am. Chem. Soc., 109, 5740 (1987)

[7] Moss RA, Okumura Y, J. Am. Chem. Soc., 114, 1750 (1992)

[8] Cho I, Shin JS, Polym.(Korea), 15(2), 170 (1991)

[9] Shin JS, J. Korean Ind. Eng. Chem., 2(1), 64 (1991)

[10] Bae DH, Kim KS, Shin JS, J. Korean Ind. Eng. Chem., 3(2), 335 (1992)

[11] Cho I, Chung KC, Macromolecules, 17, 2935 (1984)

[12] Cho I, Chung KC, Macromolecules, 21, 565 (1988)

[13] Cho I, Park JG, Chem. Lett., 977 (1987)

[14] Cho I, Kim YW, Polym. Bull., 24, 545 (1990)

[15] Cho I, Kim SH, Shin JS, J. Korean Ind. Eng. Chem., 3(2), 273 (1992)

[16] Cho I, Jeong SW, Shin JS, Polym.(Korea), 18(1), 23 (1994)

[17] Shin JS, Polym.(Korea), 19(3), 379 (1995)

[18] Shin JS, J. Korean Ind. Eng. Chem., 7(6), 1142 (1996)

[19] Shin JS, J. Korean Ind. Eng. Chem., 9(5), 763 (1998)

[20] Allcock HR, Chem. Mater., 6, 1476 (1994)

[21] Allcock HR, Phosphorus-Nitrogen Compounds, Academic Press, New York (1972)

[22] Kumar D, Gupta AD, Khullar M, J. Polym. Sci. A: Polym. Chem., 31, 707 (1993)

[23] Horacek H, Pieh S, Polym. Int., 49, 1106 (2000)

[24] Wu Q, Lu J, Qu B, Polym. Int., 52, 1326 (2003)

[25] Levchik SV, Levchik GF, Balabanovich AI, Weil ED, Klatt M, Angew. Makromol. Chem., 264, 48 (1999)

[26] Zhu WM, Weil ED, Mukhopadhyay S, J. Appl. Polym. Sci., 62(13), 2267 (1996)

[27] Kim HY, Shin YJ, Ji YJ, Shin JS, J. Korean Ind. Eng. Chem., 17(2), 144 (2006)

[28] Gleria M, Jaeger RD, Phosphazenes, Nova Science Publishers, New York (2004)

[29] Chang JY, Rhee SB, Cheong S, Yoon M, Macromolecules, 25, 2666 (1992)

[30] Chang JY, Ji HJ, Han MJ, Rhee SB, Cheong S, Yoon M, Macromolecules, 27(6), 1376 (1994)

[31] Chang JY, Park PJ, Han MJ, Macromolecules, 33, 321 (1998)