Chemical Reviews, Vol.98, No.3, 991-1026, 1998
The hydrolysis of RNA : From theoretical calculations to the hammerhead ribozyme-mediated cleavage of RNA
Keywords:GROUP-II INTRON;BASE-CATALYZED-HYDROLYSIS;METHYL ETHYLENE PHOSPHATE;DIVALENT METAL-IONS;MARGINALLY STABLE INTERMEDIATE;MOLECULAR-ORBITAL CALCULATIONS;PHOSPHORYL-TRANSFER-REACTIONS;SELF-CLEAVING RNA;TRANSITION-STATE;TETRAHYMENA RIBOZYME