Journal of Chemical Thermodynamics, Vol.38, No.12, 1640-1650, 2006
Partial molar volumes and heat capacities of the N-acetyl amide derivatives of the amino acids asparagine, glutamine, tyrosine, and lysine monohydrochloride in aqueous solution at temperatures from T=288.15 K to T=328.15 K
The partial molar volumes, V-2(o), and partial molar heat capacities, C-p(o).(2), at infinite dilution have been determined for the compounds N-acetylasparaginamide, N-acetylglutaminamide, N-acetyltyrosinamide, and N-acetyllysinamide monohydrochloride in aqueous solution at T = (288.15, 298.15, 313.15, and 328.15) K. These results, along with the literature data for the compound N-acetylglycinamide, have been used to calculate the amino acid side-chain contributions to the thermodynamic properties. These side-chain contributions are compared with those obtained using small peptides as side-chain model compounds. (c) 2006 Elsevier Ltd. All rights reserved.
Keywords:partial molar volume;partial molar heat capacity;N-acetyl amino acid amides;amino acid side-chain contributions;group additivity;aqueous solution