Structure and catalytic activity of double copper-manganese oxide catalysts supported on MgF2 and Al2O3 have been studied. All samples were calcined at 400 degrees C and those supported on Al2O3 also at 550 and 950 degrees C. The properties of surface species have been characterized by low temperature adsorption of nitrogen, XRD and TPR-H-2. The catalytic activities have been tested in low-temperature CO oxidation and in NO reduction by propene. The supported oxides react with each other during calcination to form CuMn2O4 spinel. The spinel seems to be responsible for the catalytic activity of the double copper-manganese catalysts. The temperature of calcination changes the strength of interaction between the active phase and the supports influencing the catalytic activity.