A new series of 5 analogues of N-nicotinyl-L-homoserine lactones and 3 analogues of N-sulfonyl-L-homoserine lactones were designed by molecular modeling using SYBYL packages and synthesized by means of the solid phase organic synthesis method. This was followed by a bacterial test designed to confirm their quorum-sensing inhibition ability, antifouling ability, and antibacterial efficacy. The 8 synthesized compounds were found to be effective as quorum-sensing antagonists, and they were also proven to have antibacterial effects.