화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.31, No.3, 233-238, May, 2007
Export Citation
Poly(glycolic acid)를 심선에 지닌 의료용 흡수성 복합재료의 생분해 거동
Degradation Behavior of Medical Resorbable Composite Materials Interposed in the Poly(glycolic acid)
이찬우†
  • 호서대학교 참단산업공학과
Chan Woo Lee†
  • Department of Innovative Industrial Technology, Hoseo University, Asan-City 336-795, Korea
E-mail:
초록
Poly(glycolic acid)(PGA)와 poly[(R)-3-hydroxybutyrate](P3HB) 및 poly(butylenes succinate-co-L-lactate)(PBSL) 복합재료를 체내에서 서로 다른 가수분해속도를 보완하여 저가의 의료용 흡수성 복합재료로 응용하고자 연구하였다. 그 결과 PBSL/PGA와 P3HB/PGA 복합섬유는 인산염 완충용액 중에서 가수분해되는 것이 확인되었으며, PBSL/PGA 복합섬유는 PGA의 분해에 의해 발생된 glycolic acid에 의해 PBSL의 분해가 촉진되는 메카니즘이 확인되었다. PBSL/PGA 복합섬유는 lipase PS가 존재함에 의해 상당히 빠른 가수분해가 발생하는 것이 확인되었으며, 대기중에서는 거의 가수분해가 발생되지 않는 것을 알 수 있었다. P3HB/PGA 복합섬유 역시 대기중에서 적당한 인장강도를 유지하고 있는 것이 확인된 것으로 보아 본 연구를 통하여 이들 복합섬유는 의료용 흡수성 복합재료와 환경 적합재료로서 응용이 가능할 것으로 판단된다.
The purpose of the study is to apply composites of poly(glycolic acid)(PGA) with [poly(R)- 3-hydroxybutyrate](P3HB) or poly (butylenes succinate-co-L-lactate)(PBSL) as medical resorbable composite materials with the complement of hydrolysis rate of each component. As a result, it was confirmed that the PBSL/PGA and P3HB/PGA composite fiber were hydrolyzed in phosphate buffer solution. Also, it has been revealed that the degradation of PBSL/PGA are accelerated due to PGA producing glycolic acid which can act as a catalyst. In addition, the hydrolysis of PBSL/PGA was found to be accelerated by the presence of lipase PS. When the PBSL/PGA composite fiber was placed in the air, not much hydrolysis has proceeded. Also, it was confirmed that the P3HB/PGA composite fiber maintained proper tensile strength in the air. Therefore, these complex fibers can be adapted to use as environmentally suitable, medically absorbable composite materials.
Keywords:phosphate buffer;decomposition;hydrolysis;degradation;composite fibrous;medical resorbable composite materials
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