This paper focuses on a case study of financing a project of an integrated nuclear desalination system at la Skhira site in Tunisia. More specifically, it shows the financial characteristics of this project, known as TUNDESAL, the main financing mechanisms that can be used, and the principal actions required to attract the potential investors and lenders. The paper describes the basic requirements for the deployment of nuclear energy in a developing or an emerging country, with no previous experience of nuclear power; the specific financial considerations corresponding to the particular characteristics of nuclear desalination projects: high capital costs, high level of risks and uncertainties related in particular to long construction lead times and social and environmental concerns; the main risks of these projects; the profitability study of the TUNDESAL project: application of the discounted cash flow analysis; the main financing sources for the project; the financing schemes that can be used for project implementation and comparison between these schemes in terms of benefits generated, after covering project costs and repayment of lenders and investors; the main actions to be done for making the project financially attractive in order to gain the confidence of investors and international financial institutions (optimal allocation of project risks and uncertainties, a suitable and flexible energy and water tariffs policy, etc.). The analysis has shown that in particular conditions of Tunisia, the most attractive financial scheme could be the "project financing + leasing".