The integration of membrane RO desalting and accelerated precipitation softening (APS) was evaluated for achieving high product water-recovery (> 95%) from desalting of mildly brackish surface water. A systematic approach that included laboratory RO, demonstrations, membrane scaling diagnostics, and mineral solubility analysis was undertaken to develop an effective physical/chemical APS strategy for reducing the concentration of scale-forming ions in the primary RO (PRO) concentrate. APS demineralization, as an inter-stage process, between the PRO and secondary RO (SRO) desalting, involved alkaline pH adjustment and calcite crystal seeding of the PRO concentrate, followed by microfiltration and pH reduction by acid dosing to avoid calcite scaling in the SRO stage. Colorado River water desalting case study demonstrated that, at 90% PRO recovery, the PRO concentrate stream contained barite, calcite, gypsum, and silica above their solubility limits by factors of 122, 47, 1.1, and 0.8, respectively. Further desalting was not feasible with traditional scale-control strategies (e.g., pH reduction and antiscalant addition). However, APS demineralization enabled significant concentration reduction of calcium (> 90%), barium (> 95%), and strontium (similar to 78%) and moderate reduction (10-20%) of magnesium and silica. APS kinetics were favorable even in the presence of antiscalant carryover from the PRO stage. The study demonstrated that high recovery desalination of up to 98% is feasible with the PRO-APS-SRO sequence, which reduces the limitations imposed by membrane scaling. (c) 2007 Elsevier B.V. All rights reserved.