화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.31, No.5, 417-421, September, 2007
Export Citation
덴드리틱 벤질 클로라이드의 효율적인 합성
Facile Synthesis of Dendritic Benzyl Chlorides from Their Alcohols with Methanesulfonyl Chloride/Et3N
이재욱†, 한승철, 김희주1, 김정환1, 이언엽1, 김병기1, 성새름1, 강화신1, 김지현2, 허도성3
  • 동아대학교 의생명과학과
  • 1동아대학교 화학과
  • 2동국대학교 생명화학공학과
  • 3인제대학교 의생명화학과
Jae Wook Lee†, Seung Choul Han, Hee Joo Kim1, Jung Hwan Kim1, Un Yup Lee1, Byoung-Ki Kim1, Sae Reum Sung1, Hwa-Shin Kang1, Ji Hyeon Kim2, and Do-Sung Huh3
  • Department of Medical Bioscience, Dong-A University, Hadan-2-dong, Busan 604-714, Korea
  • 1Department of Chemistry, Dong-A University, Hadan-2-dong, Busan 604-714, Korea
  • 2Department of Chemical & Biochemical Engineering, Dongguk University, Seoul 100-715, Korea
  • 3Department of Biomedicinal Chemistry, Inje University, Gim Hai 621-749, Korea
E-mail:
초록
덴드리틱 벤질 알코올을 트리에틸아민과 메탄술포닐클로라이드와 반응시켜서, 덴드리틱 벤질 클로라이드의 효율적인 합성이 이루어졌다. 이 반응은 히드록시기의 메실화 반응과 염소화 반응의 2단계 반응으로 이루어지는데, 중간체의 분리없이 한 반응 용기내에서 반응이 진행되는 경제적인 방법이다.
A successful rapid synthesis of dendritic benzyl chlorides from dendritic benzyl alcohols using methanesulfonyl chloride/Et3N as activating agents was described. In this method, each dendritic benzyl chloride can be prepared in one pot: no isolation of intermediate mesylated dendrons is required. The key steps in the syntheses of dendritic benzyl chlorides were the mesylation of the hydroxymethyl group followed by the chlorination by in-situ generated triethylammonium chloride.
Keywords:benzylic alcohol;chlorination
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