Reduction of isophorone with sodium borohydride is studied in anionic, cationic, and nonionic micellar media. Ionic micelles are found to be selective toward 1,4 products. The selectivity ratio of 1,4/1,2 products was found to increase from 0.75 to 1.6 in the presence of anionic micelles of SDS, and in the presence of cationic micelles of CTAB it increased up to 1.5. The two-phase reaction takes place in the kinetically controlled regime. The volumetric rate of the reaction increases with an increase in SDS concentration. The change in selectivity is mainly attributed to the orientation of isophorone in the micellar media, while the increase in reaction rate is attributed to increased solubility in the micellar solution.