Journal of the American Chemical Society, Vol.129, No.17, 5328-5328, 2007
Design of chiral auxiliaries for the allene ether Nazarov cyclization
A 1,3- or a 1,4-cis axial tert-butyldimethylsilyloxy substituent on the pyranose derived chiral auxiliary for the allene ether Nazarov cyclization leads to products in high optical purity. alpha-Pyranose and beta-pyranose derived auxiliaries lead to enantiomeric products.