The hydrogen abstraction reaction CF3CHFCF3 + OH has been studied by a dual-level direct dynamics method. The variational transition state calculations are performed with small curvature tunneling (SCT), and the interpolated single-point energies (ISPE) approach is employed to correct the classical energy profile. The rate constants are evaluated at the B3LYP/6-311++G(3df, 2p)//B3LYP/6-311G(d, p) level over the temperature range of 270-2000 K. The calculated results show reasonable agreement with the available experimental data in the 270-463 K range. It is found that the variational effect is significant for this reaction, and the tunneling effect is smaller. (C) 2002 Elsevier Science B.V. All rights reserved.