Magic angle spinning (MAS) from L- and D-glutamic acid-HCl at 14.1 T produces highly structured and very similar NMR spectra. Lines from all 4 oxygen sites are readily distinguished and assigned. These O-17 NMR spectra are very different from the previously reported O-17 spectrum of the D,L-form presumably because that was a racemic crystal. O-17 NMR from L-monosodium glutamate-HCl is very different again requiring the application of double angle rotation and 3 quantum MAS NMR to provide resolution of 5 different sites. Hence high resolution O-17 solid state NMR techniques offer possible new insight into biochemical bonding processes. (C) 2003 Elsevier Science B.V. All rights reserved.