A selective 2D intermolecular zero-quantum coherences pulse sequence, SEL-HOMOGENIZED sequence, was developed for high-resolution NMR spectra in inhomogeneous fields. The sequence designed to effectively suppress strong solvent signals and other trivial signals can greatly decrease the t(1) noise artifacts. In the homogeneous-like 1D spectrum extracted from the 2D data, chemical shifts, coupling constants, multiplicity patterns, and relative peak areas are almost independent of the magnetic field inhomogeneity. Compared to the HOMOGENIZED sequence, the new sequence provides a total sensitivity enhancement of two times. It was also demonstrated that the theoretical predictions were in excellent agreement with the experimental results. (C) 2004 Elsevier B.V. All rights reserved.