Chemie Ingenieur Technik, Vol.68, No.12, 1537-1545, 1996
Liposomes - Structures and Production
The general public has only recently become familiar with liposomes through their use in cosmetics although a wide range of applications has long been known in the scientific literature. Depending upon the pertinent application very different liposomes are required, which has led to a large number of methods for their production. This article describes the principal processes : rotor/stator dispersion, the injection method, dialysis, extrusion, and homogenisation. The most suitable methods for industrial use are rotor/stator emulsification, the injection method, extrusion, and homogenisation. Examination of commercially available liposame-containing products shows that high-value products such as cosmetics and pharmaceuticals predominate - commercial use of liposomes is often limited by the sophisticated production methods and expensive raw materials.
Keywords:LARGE-SCALE PRODUCTION;PRESSURE