In this contribution we report three new pure absorption mode deuterium 3D NMR experiments to analyse spectra of isotopically enriched solutes dissolved in weakly orienting liquid crystals. The potentialities of these 3D strategies are illustrated using the perdeuterated 1-butanol, a prochiral molecule of C-s symmetry in average, dissolved in a chiral mesophase made of poly-gamma-benzyl-L-glutamate. The experimental results obtained for the three types of experiments are discussed and compared. (C) 2005 Elsevier B.V. All rights reserved.