Fullerene vesicles were fabricated from a neutral methanofullerene derivative with hydrophobic-hydrophobic-hydrophilic structure (TDC60). For the first time, a water-insoluble organic molecule of pyrene was encapsulated into the vesicles and resulted in novel organic core-shell suprastructure and the photophysical properties were researched systemically. (c) 2005 Elsevier B.V. All rights reserved.