Chemistry Letters, Vol.29, No.1, 50-51, 2000
A simple synthetic method for 3-trifluoroacetylated 4-aminoquinolines from 4-dimethylaminoquinoline by novel trifluoroacetylation and N-N exchange reactions
Acylation of 4-dimethylaminoquinoline with 1-trifluoroacetyl-4-dimethylaminopyridinium trifluoroacetate proceeded cleanly to give 3-trifluoroacetyl-4-dimethylaminoquinoline which underwent nucleophilic aromatic substitutions with various amines to afford the corresponding N-N exchanged 3-trifluoroacetyl-4-aminoquinolines in excellent yields.