Chemistry Letters, Vol.29, No.6, 610-611, 2000
Asymmetric synthesis of the A-ring part of ciguatoxin by the strategy based on diastereoselective hydroboration and ring closing metathesis
Asymmetric synthesis of the A-ring part of a marine toxin ciguatoxin (CTX1B) was achieved by the strategy based on ring closing metathesis (RCM), where introduction of the C5 asymmetric center was performed by diastereocontrolled hydroboration of a vinyl ether moiety.