Chemistry Letters, Vol.29, No.10, 1174-1175, 2000
First asymmetric photochemistry with nucleosides and DNA: Enantiodifferentiating Z-E photoisomerization of cyclooctene
Thymidine and uridine, as well as calf thymus DNA (ctDNA), have been shown for the first time to function as chiral photosensitizers in aqueous solution, to effect the enantiodifferentiating photoisomerization of (Z)-cyclooctene, giving the chiral (E)-isomer in enantiomeric excesses of up to 15%.