Hydrothermal reaction of Cu(CH3COO)(2). 5H(2)O and NdCl3. 6H(2)O with orotic acid (2.6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, H(3)dtpc) in water gave rise to a novel polymeric complex, [Nd2Cu3(Hdtpc)(6)(H2O)(4)](n), with two-dimensional layer structure. Nd(III) atom is nine-coordinated by nitrogen and oxygen atoms of Hdtpc ligands and water molecules and Cu(II) atom is four-coordinated by two chelated Hdtpc in a square planar geometry. The hydrogen bond interactions among layers lead to the formation of three-dimensional network structure.