Chemistry Letters, Vol.31, No.1, 24-25, 2002
Dynamic kinetic resolution with enantioselective borohydride reduction catalyzed by optically active beta-ketoiminato cobalt(II) complexes: Highly diastereo- and enantioselective preparation of optically active anti-aldol compounds
Optically active anti-2-alkyl-3-hydroxy esters were stereoselectively obtained from the corresponding 2-alkyl-3-keto esters using enantioselective borohydride reduction along with dynamic kinetic resolution in the presence of optically active beta-ketoiminato cobalt complex catalysts. The reduction system provided an alternative preparation for anti-aldol compounds with high diastereo- and enantioselectivities.