Chemistry Letters, Vol.31, No.1, 92-93, 2002
A synthesis of AB-ring model system of taxane framework by way of intramolecular Knoevenagel cyclization
Methyl 1,2-dialkoxy-11,11-dimethyl-9-oxobicyclo[5.3.1]-undec-7-en-8-carboxylate 19 was synthesized by cesium fluoride-mediated intramolecular Knoevenagel reaction of methyl 4-(1,8-dialkoxy-2,2-dimethyl-3-oxocyclooctyl)-3-oxobutanonate 18.