An extremely high insulin-mimetic activity of bis(1,4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridinolato)zinc(II) complex

Katoh A; Tsukahara T; Saito R; Ghosh KK; Yoshikawa Y; Kojima Y; Tamura A; Sakurai H

Chemistry Letters, Vol.31, No.1, 114-115, 2002

Katoh A, Tsukahara T, Saito R, Ghosh KK, Yoshikawa Y, Kojima Y, Tamura A, Sakurai H

Vanadyl and zinc(II) complexes with VO(O2S2) and Zn(O2S2) coordination mode, respectively, were synthesized. Among them, bis(1,4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridinolato)zinc(II) complex exhibited an extremely high insulin-mimetic activity (IC50 = 0.04 mM when IC50 value of a positive control, VOSO4 was estimated to be 1.0 mM) compared to vanadyl and zinc(II) complexes reported previously.