Chemistry Letters, Vol.31, No.10, 1038-1039, 2002
The Biginelli condensation: A novel and efficient regioselective synthesis of dihydropyrimidin-2(1H)-ones using lithium bromide
Various substituted 3,4-dihydropyrimidin-2(1H)-ones were synthesised in one-pot reaction of aldehydes, beta-ketoesters and urea using LiBr in tetrahydrofuran in excellent yields without any side reactions as observed by Biginelli and others.