Chemistry Letters, Vol.32, No.3, 266-267, 2003
Thermo responsive DNA/polymer conjugate for intelligent antisense strategy
The conjugate between 20-mer antisense oligodeoxynucleotides (ODN) and thermo-responsive polymer, poly(N-isopropylacrylamide) (PNIPAAm), was prepared. Hybridization reaction between the conjugate and their target RNA was modulated by conformational change of polymer moiety depending on temperature condition.