Chemistry Letters, Vol.32, No.4, 320-321, 2003
Synthesis and optical resolution of an anti-0,0'-dialkylated calix[4]arene
Proximally O,O'-disiloxane-bridged calix[4]arene (1) was treated with benzyl bromide in the presence Of Cs2CO3 to afford, after desilylation, anti-O,O'-dibenzylcalix[4]arene (4a) in 90% yield. Chromatographic separation of its diastereomeric (S)-2-methoxy-2-(1-naphthyl)propionic esters allowed the first optical resolution of this kind of dialkylated calix[4]arenes.