The first solid phase synthesis of 1,2,4-oxadiazolines via 1,3-dipolar cycloaddition of nitrile oxide generated in situ on solid support with a variety of imines is described. The synthetic sequences were performed in parallel one-pot fashion. Cleavage from the support under two different mild conditions afforded a library of 1,2,4-oxadiazolines in good yields and purity.