Chemistry Letters, Vol.33, No.2, 122-123, 2004
Synthesis of pyrimidines via base-induced condensation of alpha-chloro oxime derivatives
A facile synthesis of 2,4,6-trisubstituted pyrimidines from the reaction of alpha-chloro oxime ethers with Grignard reagents has been developed. Alkyl and aryl groups can be easily introduced at the 2-position of the pyrimidine core. In addition, a synthesis of unsymmetrical pyrimidines has been examined.