Chemistry Letters, Vol.33, No.4, 438-439, 2004
A facile approach to 2-CF3-substituted seven-membered oxacycles via stereoselective preparation and cope rearrangement of 2-CF3-cis-2,3-bis(alkenyl)oxiranes
Stereoselective preparation and Cope rearrangement of 2-CF3-substituted cis-2,3-bis(alkenyl)oxiranes provides a convenient route to a diverse of 2-CF3-4,5-dihydrooxepins. The reaction sequence followed by reduction or oxidation provides 2-CF3-substituted oxepanes or oxepins, respectively.