Hydrazone derivatives 2, 3, 5, 6 with H-bond donor and color-reporting chromophore were synthesized to be used as chemosensors for selective detecting anionic species via naked eye and absorption spectroscopy. The results revealed that these compounds exhibited good selectivity to fluoride anion (F-). In order to clarify the mechanism of interaction between anionic species and sensors, compound 4 was synthesized for comparative study.