Chemistry Letters, Vol.33, No.12, 1588-1589, 2004
One-pot synthesis of furo[3,2-c]oxepin-4-one derivatives by the CAN-mediated reaction of tert-butyl 2-(2-hydroxytetrahydrofuran-2-yl)acetates with alkenes
The reaction of tert-butyl 2-(2-hydroxytetrahydrofuran-2-yl)acetates with alkenes in the presence of 2 equivalents of cerium(IV) ammonium nitrate (CAN) is presented. 2,3,7,8-Tetrahydrofuro [ 3,2-c]oxepin-4(6H)-ones were formed in moderate to fair yields via 3+2-type dihydrofuran formation, followed by lactonization.