Chemistry Letters, Vol.35, No.6, 682-683, 2006
Synthesis of beta-amino ketones by iridium(III)-catalyzed direct-Mannich reaction
The direct-Mannich reaction of ketones 1, aldehydes 2, and anilines 3 was studied using catalytic amount of transition-metal complexes. The trivalent iridium complex, [IrCl2(H)(cod)](2), catalyzed the direct-Mannich reaction effectively to give various beta-amino kenotes in good yields under mild conditions.