화학공학소재연구정보센터
Chemistry Letters, Vol.35, No.9, 1008-1009, 2006
Short synthetic route toward the tricyclic core of schulzeines
The tricyclic core of marine natural products schulzeines was synthesized using N-acyliminium ion cyclization. The intermediate N-acyliminium ion was generated from treatment of alpha-hydroxy-delta-lactam with a Lewis acid. The tricyclic products were obtained as a mixture of 2 diastereomers at the C-11b stereocenter. The diastereomeric ratios were low and dependent on the Lewis acid used in the reaction.