Chemistry Letters, Vol.36, No.1, 42-43, 2007
Claisen rearrangement strategy in alkenyl dihydropyran leading to total synthesis of (+)-alpha-vetispirene and (-)-agarospirol
Total synthesis of (+)-alpha-vetispirene and (-)-agarospirol based on a Claisen rearrangement has been achieved. This is the first example of a Claisen rearrangement in an enantio-enriched alkenyl bicyclic dihydropyran system with perfect asymmetric transmission.