A new strategy, epoxide-assisted precipitation route presented in this work, allows the exfoliation-free nanosheet synthesis of Ni-3(NO3)(2)(OH)(4) by the control of dynamics of the precipitation reaction. The mechanism of growth limitation in the third direction can be explained by the bonding of the molecule resulting from the ring-opening reaction of the epoxide to the surface of primary nanosheets, preventing the thickening of the layer.