A novel MCM-41-supported sulfur palladium(0) complex was conveniently prepared from commercially available and cheap gamma-mercaptopropyltriethoxysilane via immobilization on MCM-41, followed by reacting with palladium chloride and then the reduction with hydrazine hydrate. This complex exhibited excellent performance in Sonogashira coupling reaction. (c) 2006 Elsevier B.V. All rights reserved.