Journal of Molecular Catalysis A-Chemical, Vol.256, No.1-2, 309-311, 2006
An efficient one-pot synthesis of polyhydroquinoline derivatives through the Hantzsch four component condensation
A straightforward and general method has been developed for the synthesis of polyhydroquinolines derivatives by simply combining aldehyde, ethyl acetoacetate, dimedone, and ammonium acetate in the presence of a catalytic amount of scandium triflate. This method is very easy, rapid, and high yielding reaction for the synthesis of polyhydroquinolines. (c) 2006 Elsevier B.V. All rights reserved.